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Besides to modulate the mitochondrial redox status, ALA has further been reported to be implicated in the lipid regulation through its critical roles in modulating several key enzymes such as hydroxymethylglutaryl-CoA reductase (HMG-CoA reductase) and lipoprotein lipase (LPL) (33)

doi: 10.3389/fmicb.2022.1064095 51 DridiR.EssghaierB.HannachiH.KhedherG

doi: 10.1016/j.bbrc.2003.11.081 177 DayarEKaraEYetik-AnacakGHocaogluNBozkurtOGidenerSet al

176 Non-canonical pathways: expanding the proteostasis network Beyond the canonical pathways, several non-canonical mechanisms contribute to proteostasis